Chlorotrimethylsilane → HCID 11531784, compound

HRID 908933Notes

Reaction equation

HRID 908933 reaction equation
[CH3:1][N:2]([CH3:28])[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:29][Si](C)(C)C>CC(CC)=O>[ClH:29].[CH3:28][N:2]([CH3:1])[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:4][CH2:5][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=2)=[O:11])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11531785HCID 11531785, compound

Product 1

HCID 11531784HCID 11531784, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[2-(4-fluorophenyl)ethyl]acetamide (252 mg, 0.66 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.126 ml, 1.0 mmol) was added. After 2 h the hydrochloride was isolated as a colourless solid with an m.p. of 157-160° C. and a yield of 74% (203 mg).

Sources & evidence

ORD record
ord-490bf964e95645efb4d636a31c59e955
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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