HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → HCID 11531784, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | HCID 11531785 | HCID 11531785 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 11531784 | HCID 11531784 | 74% |
Reaction Steps
2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[2-(4-fluorophenyl)ethyl]acetamide (252 mg, 0.66 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.126 ml, 1.0 mmol) was added. After 2 h the hydrochloride was isolated as a colourless solid with an m.p. of 157-160° C. and a yield of 74% (203 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-490bf964e95645efb4d636a31c59e955 |
| Source note | uspto-grants-2011_09 |