HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → HCID 11582620, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(1H-indol-3-ylmethyl)acetamide | HCID 11582621 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 11582620 | HCID 11582620 | 63% |
Reaction Steps
2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-(1H-indol-3-ylmethyl)acetamide (120 mg, 0.309 mmol) was dissolved in ethyl methyl ketone (5 ml), and chlorotrimethylsilane (0.058 ml, 0.46 mmol) was added. After 1.5 h the hydrochloride was isolated with an m.p. of 173-185° C. in a yield of 63% (82 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-cb04016a299043fbaaba7797f909ee8e |
| Source note | uspto-grants-2011_09 |