HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[4-(1H-indol-3-yl)butyl]acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[4-(1H-indol-3-yl)butyl]acetamide | HCID 11677074 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[4-(1H-indol-3-yl)butyl]acetamide hydrochloride | HCID 11677073 | 74% |
Reaction Steps
2-(4-Dimethylamino-4-phenylcyclohexylidene)-N-[4-(1H-indol-3-yl)butyl]acetamide (184 mg, 0.428 mmol) was dissolved in ethyl methyl ketone (10 ml), and chlorotrimethylsilane (0.08 ml, 0.64 mmol) was added. After 1.5 h the hydrochloride was isolated as a colourless solid with an m.p. of 185-188° C. in a yield of 74% (147 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-4189cee6df21463e8521f158bcba58e1 |
| Source note | uspto-grants-2011_09 |