反应详情

A solution of 6-(1H-Indol-3-yl)hexanoic acid cyanomethyl ester (5.72 g, 21.16 mmol) in tetrahydrofuran (160 ml) was added to a 25 percent strength ammonia solution (125 ml) and the mixture was stirred at RT for 40 h. Working up of the mixture was carried out by phase separation and extraction of the aqueous phase with THF (2×40 ml). The organic extracts were combined and washed with saturated NaCl solution (50 ml). After drying and concentration of the organic phase, the product was isolated as a colourless solid in a yield of 98% (4.75 g) with an m.p. of

1. customwas carried out by phase separation and extraction of the aqueous phase with THF (2×40 ml)
2. washwashed with saturated NaCl solution (50 ml)
3. customAfter drying
4. customconcentration of the organic phase, the product was isolated as a colourless solid in a yield of 98% (4.75 g) with an m.p. of