Chlorotrimethylsilane → HCID 11676346, compound

HRID 908946Notes

Reaction equation

HRID 908946 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]1([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:30][Si](C)(C)C>CC(CC)=O>[ClH:30].[CH3:29][N:2]([CH3:1])[C:3]1([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:11])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11676347HCID 11676347, compound

Product 1

HCID 11676346HCID 11676346, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-[4-Dimethylamino-4-(4-fluorophenyl)cyclohexylidene]-N-(3-phenylpropyl)acetamide (180 mg, 0.45 mmol) was dissolved in ethyl methyl ketone (10 ml), and chlorotrimethylsilane (0.087 ml, 0.68 mmol) was added. After 1.5 h the hydrochloride was isolated as a colourless solid with an m.p. of 209-212° C. in a yield of 65% (126 mg).

Sources & evidence

ORD record
ord-6f0b027865544881ae1d67fa69abbc9e
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

Loading…