Chlorotrimethylsilane → HCID 11676346, compound

Participants

Reaction Steps

2-[4-Dimethylamino-4-(4-fluorophenyl)cyclohexylidene]-N-(3-phenylpropyl)acetamide (180 mg, 0.45 mmol) was dissolved in ethyl methyl ketone (10 ml), and chlorotrimethylsilane (0.087 ml, 0.68 mmol) was added. After 1.5 h the hydrochloride was isolated as a colourless solid with an m.p. of 209-212° C. in a yield of 65% (126 mg).

Provenance & Evidence