HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → HCID 11705177, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexylidene]-N-[2-(1H-indol-3-yl)ethyl]acetamide | HCID 11705178 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 11705177 | HCID 11705177 | 85% |
Reaction Steps
2-[4-Dimethylamino-4-(4-fluorophenyl)cyclo hexylidene)-N-[2-(1H-indol-3-yl)ethyl]acetamide (871 mg, 2.08 mmol) was dissolved in ethyl methyl ketone (35 ml), and chlorotrimethylsilane (0.39 ml, 3.11 mmol) was added. After 1.5 h the hydrochloride was isolated as a beige-coloured solid with an m.p. of 217-221° C. in a yield of 85% (810 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-05d98d6711574cfca6507b91bcf95064 |
| Source note | uspto-grants-2011_09 |