反应详情

1.7 M KOH (70.5 ml, 120 mmol) was added to a solution of (4-dimethylamino-4-phenylcyclohexyl)acetic acid methyl ester hydrochloride (1.79 g, 5.77 mmol) in ethanol (80 ml). The mixture was stirred at RT for 16 h. The reaction mixture was concentrated and the residue was taken up in water. The aqueous phase was extracted with ether, and 5.5 M hydrochloric acid (23.6 ml, 130 mmol) was added. After concentration of the aqueous phase, the residue was extracted with ethanol, the potassium chloride which remained was separated off and the filtrate was concentrated. The product was thereby obtained as a colourless, oily compound in a yield of 95% (1.62 g).

1. concentrationThe reaction mixture was concentrated
2. additionwas added
3. extractionAfter concentration of the aqueous phase, the residue was extracted with ethanol
4. customthe potassium chloride which remained was separated off
5. concentrationthe filtrate was concentrated
6. customThe product was thereby obtained as a colourless, oily compound in a yield of 95% (1.62 g)