Chlorotrimethylsilane → HCID 11589419, compound

HRID 908966Notes

Reaction equation

HRID 908966 reaction equation
[CH3:1][N:2]([CH3:27])[C:3]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:28][Si](C)(C)C>CC(CC)=O>[ClH:28].[CH3:27][N:2]([CH3:1])[C:3]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:4][CH2:5][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:11])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11589420HCID 11589420, compound

Product 1

HCID 11589419HCID 11589419, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-phenethylacetamide (220 mg, 0.6 mmol) was dissolved in ethyl methyl ketone with gentle heating and chlorotrimethylsilane (0.113 ml, 0.9 mmol) was added. After 1.5 h it was possible to isolate a colourless, hygroscopic solid in a yield of 80% (191 mg).

Workup

  1. temperaturewith gentle heating
  2. customto isolate a colourless, hygroscopic solid in a yield of 80% (191 mg)

Sources & evidence

ORD record
ord-534ef5d025ff41ce9cd6fc33d7449a80
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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