Chlorotrimethylsilane → HCID 11711633, compound

HRID 908967Notes

Reaction equation

HRID 908967 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])[CH2:5][CH2:4]1.[Cl:30][Si](C)(C)C>CC(CC)=O>[ClH:30].[CH3:29][N:2]([CH3:1])[C:3]1([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 11711634HCID 11711634, compound

Product 1

HCID 11711633HCID 11711633, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-(4-phenylbutyl)acetamide (194 mg, 0.49 mmol) was dissolved in ethyl methyl ketone, and chlorotrimethylsilane (0.093 ml, 0.74 mmol) was added. After 1.5 h it was possible to filter off the product with suction as a colourless, hygroscopic solid in a yield of 30% (63 mg).

Workup

  1. filtrationto filter off the product with suction as a colourless, hygroscopic solid in a yield of 30% (63 mg)

Sources & evidence

ORD record
ord-5e72816c9f124060bf723d16bbb79b80
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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