HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-phenyl-acetamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-phenyl-acetamide | HCID 11646444 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-phenyl-acetamide Hydrochloride | HCID 11646443 | 64% |
Reaction Steps
Chlorotrimethylsilane (0.124 ml) and water (9 μl) were added to a solution of the less polar diastereoisomer of 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-phenyl-acetamide (300 mg, 0.9 mmol) in ethyl methyl ketone (2 ml). After 18 h it was possible to isolate the hydrochloride as a colourless solid in a yield of 64% (210 mg) (Example 55).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-c2d71c43705643e3bfdeb5b7d76848e4 |
| Source note | uspto-grants-2011_09 |