反应详情

Chlorotrimethylsilane (0.118 ml) and water (8 μl) were added to a solution of the less polar diastereoisomer of 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-(4-fluoro-phenyl)-acetamide (300 mg, 0.8 mmol) in ethyl methyl ketone (2 ml) and a little methanol. After concentration it was possible to isolate the hydrochloride in a yield of 397 mg (quantitative) (Example 57).

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