HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 11718081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-(4-Dimethylamino-4-phenyl-cyclohexyl)-N-(4-fluoro-phenyl)-acetamide | HCID 11718082 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 11718081 | HCID 11718081 | — |
Reaction Steps
Chlorotrimethylsilane (0.118 ml) and water (8 μl) were added to a solution of the less polar diastereoisomer of 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-(4-fluoro-phenyl)-acetamide (300 mg, 0.8 mmol) in ethyl methyl ketone (2 ml) and a little methanol. After concentration it was possible to isolate the hydrochloride in a yield of 397 mg (quantitative) (Example 57).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017630B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-48562edb656e45f2bb8f2fdbdbc99adf |
| Source note | uspto-grants-2011_09 |