Water → HCID 11711119, compound

HRID 909001Notes

Reaction equation

HRID 909001 reaction equation
[Cl:1][Si](C)(C)C.O.[CH3:7][N:8]([CH3:33])[C:9]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:14][CH2:13][CH:12]([CH2:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[O:17])[CH2:11][CH2:10]1>CC(CC)=O>[ClH:1].[CH3:33][N:8]([CH3:7])[C:9]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:10][CH2:11][CH:12]([CH2:15][C:16]([NH:18][C:19]2[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=2)=[O:17])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 11711120HCID 11711120, compound

Product 1

HCID 11711119HCID 11711119, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Chlorotrimethylsilane (0.097 ml) and water (7 μl) were added to a solution of the less polar diastereoisomer of 2-(4-dimethylamino-4-phenyl-cyclohexyl)-N-(4-methoxy-phenyl)-acetamide (255 mg, 0.7 mmol) in ethyl methyl ketone (2 ml). The hydrochloride was extracted as an oil with hexane and isolated in a quantitative yield.

Workup

  1. extractionThe hydrochloride was extracted as an oil with hexane
  2. customisolated in a quantitative yield

Sources & evidence

ORD record
ord-c49091d1abd645d18b0a23c307127f83
Source dataset
uspto-grants-2011_09
Patent number
US08017630B2

Reaction notes

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