Methylamine → HCID 178482759, compound

HRID 909002Notes

Reaction equation

HRID 909002 reaction equation
[Cl:1][C:2]1[C:3]([F:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:11][NH2:12]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([F:10])=[C:4](/[CH:5]=[N:12]/[CH3:11])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 7363353-Chloro-2-fluorobenzaldehyde

Product 1

HCID 178482759HCID 178482759, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 3-chloro-2-fluoro-benzoaldehyde (Oakwood, 97%) (1.59 g, 10.0 mmol) and methyl amine (2.0 M in THF, Aldrich, 7.5 mL, 15.0 mmol) in CH2Cl2 (20 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried under reduced pressure to afford [[1-(3-chloro-2-fluoro-phenyl)-meth-(E)-ylidene]-methyl-amine (1.72 g, 100%) as colorless oil which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-6d55a2d313e340b49ff7ea2f9f82a35e
Source dataset
uspto-grants-2011_09
Patent number
US08017607B2

Reaction notes

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