Methylamine → HCID 178482757, compound

HRID 909003Notes

Reaction equation

HRID 909003 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][NH2:11]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:5]=[N:11]/[CH3:10])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 114773-Chlorobenzaldehyde

Product 1

HCID 178482757HCID 178482757, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 3-chloro-benzoaldehyde (Aldrich, 97%) (4.21 g, 30.0 mmol) and methyl amine (2.0 M in THF, Aldrich, 22.5 mL, 45.0 mmol) in CH2Cl2 (50 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried under reduced pressure to afford [[1-(3-chloro-phenyl)-meth-(E)-ylidene]-methyl-amine (4.60 g, 100%) as colorless oil which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-2ce58cd3cce344cea607adefdda18b8d
Source dataset
uspto-grants-2011_09
Patent number
US08017607B2

Reaction notes

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