Methylamine → HCID 178482786, compound

HRID 909004Notes

Reaction equation

HRID 909004 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([F:10])[CH:3]=1.[CH3:11][NH2:12]>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[N:12]/[CH3:11])=[C:4]([F:10])[CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 27249084-Chloro-2-fluorobenzaldehyde

Product 1

HCID 178482786HCID 178482786, compoundYield 129%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 4-chloro-2-fluoro-benzoaldehyde (Matrix Sci, 3.17 g, 20.0 mmol) and methyl amine (2.0 M in THF, Aldrich, 15 mL, 15.0 mmol) in CH2Cl2 (20 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried under reduced pressure to afford [[1-(4-chloro-2-fluoro-phenyl)-meth-(E)-ylidene]-methyl-amine (3.32 g, 97.0%) as colorless oil which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-1d20a16282d04d55b250733efc63a97b
Source dataset
uspto-grants-2011_09
Patent number
US08017607B2

Reaction notes

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