Hydrochloric Acid → HCID 86594424, compound

HRID 909199Notes

Reaction equation

HRID 909199 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C@@H:4]([NH:10]C(OC(C)(C)C)=O)[CH2:5][CH2:6][N:7]([CH3:9])[CH3:8].[ClH:19]>O1CCOCC1>[ClH:19].[ClH:19].[NH2:10][C@@H:4]([CH2:5][CH2:6][N:7]([CH3:9])[CH3:8])[C:3]([O:2][CH3:1])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58797296(S)-2-tert-Butoxycarbonylamino-4-dimethylaminobutyric acid methyl ester

Product 1

HCID 86594424HCID 86594424, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a cooled (0° C.) solution of (S)-2-tert-butoxycarbonylamino-4-dimethylaminobutyric acid methyl ester (23.4 g, 90 mmol) in dioxane (100 mL) was added drop-wise HCl (225 mL, 4M in dioxane). The mixture was warmed to room temperature and stirred for 3 hours. The solid was filtered, washed with ether (3×100 mL), and dried under high vacuum to afford 20.2 g of product (96% yield).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with ether (3×100 mL)
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-cd3df534367544b2b5241f26db04a51f
Source dataset
uspto-grants-2011_09
Patent number
US08017641B2

Reaction notes

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