Hydrochloric Acid → HCID 67410831, compound

HRID 909210Notes

Reaction equation

HRID 909210 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:22])[C@@H:5]([NH:14]C(OC(C)(C)C)=O)[CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[ClH:1].[ClH:1].[CH3:2][O:3][C:4](=[O:22])[C@@H:5]([NH2:14])[CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67412729HCID 67412729, compound

Product 1

HCID 67410831HCID 67410831, compoundYield 46%

Procedure

HCl (0.45 mL of 4M in dioxane) was added to (S)-2-tert-Butoxycarbonylamino-4-piperidin-1-yl-butyric acid methyl ester and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure and dried under high vacuum for 16 hours to provide the product (46% yield).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried under high vacuum for 16 hours

Sources & evidence

ORD record
ord-29b2caa72050464187c879037eab447f
Source dataset
uspto-grants-2011_09
Patent number
US08017641B2

Reaction notes

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