2-Aminophenol → Indole

HRID 909247Notes

Reaction equation

HRID 909247 reaction equation
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6][C:5](=O)O[C:2]2=O.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1O.NC1C=CC=CC=1S>>[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:5]1[NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=2[CH:2]=1.[NH:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=2[CH:2]=[CH:5]1

Participants

5

Reactant 3

HCID 58012-AminophenolHCID 8359Isatoic AnhydrideHCID 87132-Aminothiophenol

Product 2

HCID 798IndoleHCID 7359662-(2-Aminophenyl)indole

Procedure

reacting isatoic anhydride with 2-aminophenol or 2-aminothiophenol to obtain a 2-(2-aminophenyl)benzazole (wherein the term “benzazole” means benzoxazole or benzothiazole);

Sources & evidence

ORD record
ord-eedffd90d75849dd8f102c4becb53bb1
Source dataset
uspto-grants-2011_09
Patent number
US08017769B2

Reaction notes

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