Methanol → HCID 178515937, compound

HRID 909284Notes

Reaction equation

HRID 909284 reaction equation
[N:1]1[N:2]([C:10]2[CH:11]=[C:12](C)[CH:13]=[CH:14][C:15]=2[OH:16])[N:3]=[C:4]2C=CC=C[C:5]=12.C(=O)([O-])[O-].[Na+].[Na+].CO>ClC(Cl)Cl>[C:15]1([O-:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1

Participants

5

Reactant 3

HCID 887MethanolHCID 10340Sodium CarbonateHCID 17113Drometrizole

Product 1

HCID 178515937HCID 178515937, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.4 mmol of [Ir(1-phenylisoquinoline)2Cl]2 of Formula 44 and 0.88 mmol of 3-(2H-benzotriazole-2-yl)-4-hydroxyphenyl methane of Formula 45 and 2.0 mmol of sodium carbonate were added to a 250 ml branched flask and dissolved in 40 ml of trichloromethane and 15 mL of methanol to react in a nitrogen atmosphere at room temperature for 2 to 10 hours. After the reaction was completed, the reaction solution was Celite filtered and precipitated in hexane to obtain triazole phenolate represented by Formula 3. The obtained red solid was refined using silica gel column (methylene chloride:acetone=10:1). The structure of the final product was analyzed using a 1H NMR spectrum:

Workup

  1. filtrationfiltered
  2. customprecipitated in hexane

Sources & evidence

ORD record
ord-2952bad019534135b2f8bfc2bd40de31
Source dataset
uspto-grants-2011_09
Patent number
US08017787B2

Reaction notes

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