Hydrochloric Acid → HCID 178524574, compound

HRID 909295Notes

Reaction equation

HRID 909295 reaction equation
[OH:1][C:2]1[C:7]([C:8]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:9]=2[C:10]([O:12]C)=[O:11])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl>CO>[OH:1][C:2]1[C:7]([C:8]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:9]=2[C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178498468HCID 178498468, compound

Product 1

HCID 178524574HCID 178524574, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2-(2-hydroxypyridin-3-yl)-5-nitrobenzoate (Reference Compound No. 1-3-(2), 300 mg, 1.09 mmol) was dissolved in methanol (2 mL), then conc. HCl (5 mL) was added thereto, and then the reaction mixture was refluxed overnight. The solvent was removed under reduced pressure to give the titled reference compound (263 mg) as a yellow solid. (Yield 93%)

Workup

  1. temperaturethe reaction mixture was refluxed overnight
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-26e12298993745ecaa17fd7a06c57fca
Source dataset
uspto-grants-2011_09
Patent number
US08017775B2

Reaction notes

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