Ammonium Hydroxide → HCID 67411190, compound

HRID 909382Notes

Reaction equation

HRID 909382 reaction equation
[Br:1][C:2]1[CH:15]=[C:14]([CH:16]2[C:25]3[C:24](=[O:26])[CH2:23][CH:22]([CH2:27][CH2:28][CH3:29])[CH2:21][C:20]=3[NH:19][C:18]([CH3:30])=[C:17]2[C:31]#[N:32])[CH:13]=[C:12]([O:33][CH2:34][CH3:35])[C:3]=1[O:4][CH2:5][CH2:6]OS(C)(=O)=O.[NH4+:36].[OH-]>O1CCOCC1>[NH2:36][CH2:6][CH2:5][O:4][C:3]1[C:12]([O:33][CH2:34][CH3:35])=[CH:13][C:14]([CH:16]2[C:25]3[C:24](=[O:26])[CH2:23][CH:22]([CH2:27][CH2:28][CH3:29])[CH2:21][C:20]=3[NH:19][C:18]([CH3:30])=[C:17]2[C:31]#[N:32])=[CH:15][C:2]=1[Br:1]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 86761408HCID 86761408, compound

Product 1

HCID 67411190HCID 67411190, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of the product of step b (3.38 g) and conc. aq. NH4OH (60 ml) in dioxane (90 ml) was stirred at 80° C. in an autoclave for 17 h. The mixture was concentrated in vacuo. Yield: 3.82 g (MeSO3H salt). MS-ESI: [M+H]+=488.2/490.2

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-557b0a45734e46b7aef767a7e4b612c2
Source dataset
uspto-grants-2011_09
Patent number
US08017782B2

Reaction notes

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