Dichloromethane → HCID 25064373, compound

HRID 909402Notes

Reaction equation

HRID 909402 reaction equation
C(N([CH2:6][C:7]1[CH:35]=[CH:34][C:10]2[C:11](=[O:33])[N:12]([C:14]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:13][C:9]=2[CH:8]=1)CC)C.C([Cl:41])(=O)OCC.C(Cl)Cl>CC(O)C>[Cl:41][CH2:6][C:7]1[CH:35]=[CH:34][C:10]2[C:11](=[O:33])[N:12]([C:14]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:13][C:9]=2[CH:8]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 10928Ethyl chloroformateHCID 66907841HCID 66907841, compound

Product 1

HCID 25064373HCID 25064373, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

20.0 g of 6-(diethylamino)methyl-2-triphenylmethyl-1,2-benzisoxazol-3(2H)-one and 5.1 mL of ethyl chlorocarbonate were added to 60 mL of methylene chloride. This was then stirred for 3 hours at room temperature, and 140 mL of 2-propanol was added dropwise into the reaction mixture over a period of 30 minutes. The result was stirred for 2 hours at 5-15° C. and solids were filtered to obtain 16.6 g of 6-(chloromethyl)-2-triphenylmethyl-1,2-benzisoxazol-3(2H)-one in the form of a pale yellowish-white solid.

Workup

  1. stirringThe result was stirred for 2 hours at 5-15° C.
  2. filtrationsolids were filtered

Sources & evidence

ORD record
ord-875e9a89a27348e9813ace68b4dc8929
Source dataset
uspto-grants-2011_09
Patent number
US08017789B2

Reaction notes

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