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HRID909557

反应详情

EQUATION

反应方程式

HRID 909557 的结构方程式

REACTANTS

反应物

1
结构：COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C(=O)OCc3ccccc3)[nH]2)c1
HCID66683118

未命名化合物

PRODUCTS

生成物

1
结构：COC[C@H](C)Oc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc(-c2ccc(C(=O)O)[nH]2)c1
HCID66681446

未命名化合物

收率 101.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[C].[Pd]
催化剂HCID178418390

未命名化合物

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Benzyl 5-(3-[(1S)-2-methoxy-1-methylethoxy]-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}phenyl)-1H-pyrrole-2-carboxylate (5.08 g, 9.47 mmol) synthesized in Example (76a) was dissolved in ethyl acetate (30 mL), and a 10% palladium carbon catalyst (1.10 g) was added, followed by stirring at room temperature for 3 hours under hydrogen atmosphere. After Celite filtration, the solvent was distilled off under reduced pressure to afford the desired compound as a white solid (4.30 g, yield ˜100%).

WORKUP

后处理

  1. filtrationAfter Celite filtration
  2. distillationthe solvent was distilled off under reduced pressure