Hydrochloric Acid → 3-(3-Bromophenethoxy)-N-cyclohexyl-N-(2-oxoethyl)propanamide

Participants

Reaction Steps

To a stirred solution of 3-(3-bromophenethoxy)-N-cyclohexyl-N-(2,2-dimethoxyethyl)propanamide (1.5 g) in acetone (30 mL) was added 2M hydrochloric acid (15 mL). The mixture was stirred for 2 h before the solvent was removed under vacuum, followed by the addition of water. The aqueous phase was extracted three times with DCM and the pooled DCM was washed once with brine, dried over sodium sulphate, filtered and the solvent removed to afford the desired material (1.5 g). This material was used in the next step directly.

Provenance & Evidence