反应详情

To a stirred solution of 3-(3-bromophenethoxy)-N-cyclohexyl-N-(2,2-dimethoxyethyl)propanamide (1.5 g) in acetone (30 mL) was added 2M hydrochloric acid (15 mL). The mixture was stirred for 2 h before the solvent was removed under vacuum, followed by the addition of water. The aqueous phase was extracted three times with DCM and the pooled DCM was washed once with brine, dried over sodium sulphate, filtered and the solvent removed to afford the desired material (1.5 g). This material was used in the next step directly.

1. customwas removed under vacuum
2. additionfollowed by the addition of water
3. extractionThe aqueous phase was extracted three times with DCM
4. washthe pooled DCM was washed once with brine
5. dry with materialdried over sodium sulphate
6. filtrationfiltered
7. customthe solvent removed