反应详情

温度

25 °C

A mixture of tert-butyl 3-(3-(1-ethyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanoate [Example 4, Step iii)] (382 mg), DCM (5 mL) and TFA (5 mL) was stirred at 25° C. for 30 min and concentrated under vacuum to give the subtitled compound as a gum (625 mg). 1H NMR (300 MHz, CDCl3) δ 7.92 (s, 1H), 7.75 (s, 1H), 7.48 (d, J=7.6 Hz, 1H), 7.37 (t, J=7.6 Hz, 1H), 7.24 (s, 1H), 4.53 (q, J=7.4 Hz, 2H), 3.76 (t, J=5.9 Hz, 2H), 3.76 (t, J=6.0 Hz, 2H), 2.93 (t, J=6.0 Hz, 2H), 2.63 (t, J=5.9 Hz, 2H), 1.67 (t, J=7.4 Hz, 3H).

1. concentrationconcentrated under vacuum