反应详情

温度

80 °C

To N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-formylphenethoxy)propanamide [Example 10, Step ii)] (600 mg) in a 10 ml microwave vial was added toluenesulfonylmethyl isocyanide (329 mg), potassium carbonate (233 mg) and methanol (2 mL). The vial was sealed and heated at 80° C. for 40 min within a microwave before cooling to room temperature. The solvents were evaporated under vacuum followed by the addition of water, which was extracted once with ethyl acetate. The organic phase was washed once with water, dried over sodium sulphate, filtered and the solvent removed to afford desired material, which was carried onto the next step directly. MS [M+H-MeOH]+=399 (MultiMode+)

1. customThe vial was sealed
2. temperaturebefore cooling to room temperature
3. customThe solvents were evaporated under vacuum
4. additionfollowed by the addition of water, which
5. extractionwas extracted once with ethyl acetate
6. washThe organic phase was washed once with water
7. dry with materialdried over sodium sulphate
8. filtrationfiltered
9. customthe solvent removed
10. customto afford desired material, which