HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 3-Bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-Bromo-5-tert-butyl-6-hydroxy-2-methylbenzoic acid | HCID 21434120 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid phenyl ester | HCID 57421453 | — |
Reaction Steps
From 3-bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid, phenol and phosphorus oxychloride in toluene; amber oil; 1H NMR (CDCl3): δ 11.10 (s, 1H), 7.64 (s, 1H), 7.50-7.42 (m, 2H), 7.36-7.28 (m, 1H), 7.22-7.17 (m, 2H), 2.74 (s, 3H), 1.40 (s, 9H); LC-MS: Major component: m/z 269/270 (acylium ion), 363/365 (M+H), 385/387 (M+Na); Rt=2.95 min. The crude product was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022066B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-1b2d6316dd994394b75364ba78bb3dbe |
| Source note | uspto-grants-2011_09 |