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HRID910007

反应详情

EQUATION

反应方程式

HRID 910007 的结构方程式

REACTANTS

反应物

3
结构：Oc1ccccc1
HCID996

Phenol

C6H6O

结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：Cc1c(Br)cc(C(C)(C)C)c(O)c1C(=O)O
HCID21434120

3-Bromo-5-tert-butyl-6-hydroxy-2-methylbenzoic acid

C12H15BrO3

PRODUCTS

生成物

1
结构：Cc1c(Br)cc(C(C)(C)C)c(O)c1C(=O)Oc1ccccc1
HCID57421453

Phenyl 3-bromo-5-(1,1-dimethylethyl)-6-hydroxy-2-methylbenzoate

C18H19BrO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

From 3-bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid, phenol and phosphorus oxychloride in toluene; amber oil; 1H NMR (CDCl3): δ 11.10 (s, 1H), 7.64 (s, 1H), 7.50-7.42 (m, 2H), 7.36-7.28 (m, 1H), 7.22-7.17 (m, 2H), 2.74 (s, 3H), 1.40 (s, 9H); LC-MS: Major component: m/z 269/270 (acylium ion), 363/365 (M+H), 385/387 (M+Na); Rt=2.95 min. The crude product was used without purification.

WORKUP

后处理

  1. customThe crude product was used without purification