Ethyl bromoacetate → HCID 44417462, compound

HRID 910027Notes

Reaction equation

HRID 910027 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:12]=[N:13][N:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:15]=1)=[O:10].Br[CH2:23][C:24]([O:26]CC)=[O:25]>>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([O:1][CH2:23][C:24]([OH:26])=[O:25])=[C:3]([C:9]([C:11]2[CH:12]=[N:13][N:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:15]=2)=[O:10])[CH:4]=1

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 688698SBB001120

Product 1

HCID 44417462HCID 44417462, compound

Procedure

Prepared from (2-hydroxy-5-methylphenyl)-(1-phenyl-1H-pyrazol-4-yl)-methanone and ethyl bromoacetate according to GP2 and GP3: LC/MS (an 10p8): Rt 3.08 min, m/z 356.6 [M+1]+; 1H NMR (CDCl3): δ2.37 (s, 3H), 4.78 (s, 2H), 6.97 (d, J=9.0 Hz, 1H), 7.33-7.51 (m, 5H), 7.73 (d, J=6 Hz, 2H), 8.16 (s, 1H), 8.51 (s, 1H), 11.21 (br s, 1H)

Sources & evidence

ORD record
ord-0da7167259434c26ab57705d9f806039
Source dataset
uspto-grants-2011_09
Patent number
US08022063B2

Reaction notes

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