HCID 67241484, compound → HCID 57658835, compound

HRID 910032Notes

Reaction equation

HRID 910032 reaction equation
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][C:10]([O:12]CC)=[O:11])=[C:6]([C:17]([C:19]2[CH:20]=[N:21][N:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:23]=2)=[O:18])[CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([O:8][CH2:9][C:10]([OH:12])=[O:11])=[C:6]([C:17]([C:19]2[CH:20]=[N:21][N:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:23]=2)=[O:18])[CH:5]=1

Participants

4

Reactant 1

HCID 67241484HCID 67241484, compound

Product 1

HCID 57658835HCID 57658835, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of ethyl 4-nitro-2-(phenyl-1H-pyrazole-4-carbonyl)phenoxyacetate (190 mg, 0.48 mmol) and 10% Pd/C (100 mg) in MeOH (50 mL) was stirred under an atmosphere of hydrogen of 12 h, then filtered through a pad of celite and concentrated, and the product was hydrolyzed according to GP3 to give the title compound.

Workup

  1. filtrationfiltered through a pad of celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-41dfbd570a3e4f4487bac6620edbec83
Source dataset
uspto-grants-2011_09
Patent number
US08022063B2

Reaction notes

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