Ethane, 2-bromo-1,1-diethoxy- → 5-Bromoimidazo[1,2-a]pyridine hydrobromide

HRID 910075Notes

Reaction equation

HRID 910075 reaction equation
[Br:1][CH2:2][CH:3](OCC)OCC.[Br:10][C:11]1[N:16]=[C:15]([NH2:17])[CH:14]=[CH:13][CH:12]=1>C(O)CCC>[BrH:1].[Br:10][C:11]1[N:16]2[CH:2]=[CH:3][N:17]=[C:15]2[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 3008092-Amino-6-bromopyridine

Product 1

HCID 179854305-Bromoimidazo[1,2-a]pyridine hydrobromide

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Add 2-bromo-1,1-diethoxyethane (3.64 g, 18.48 mmol) to a solution of 6-bromopyridin-2-ylamine (1.0 g, 5.77 mmol) in n-butanol (40 ml). Reflux the reaction overnight, cool. Filtration of the reaction mixture gives 5-bromoimidazo[1,2-a]pyridine hydrobromide as a white solid.

Workup

  1. temperatureReflux
  2. customthe reaction overnight
  3. temperaturecool
  4. filtrationFiltration of the reaction mixture

Sources & evidence

ORD record
ord-2faed11e68ca4800a42ab2cc989a526d
Source dataset
uspto-grants-2011_09
Patent number
US08022065B2

Reaction notes

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