Hydrochloric Acid → HCID 28868307, compound

HRID 910183Notes

Reaction equation

HRID 910183 reaction equation
[C:1]1([C:7]2[C:8]([C:17]([NH2:19])=[O:18])=[C:9]([NH:12][C:13](=O)[CH2:14][CH3:15])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)C.C[O-].[Na+].Cl>O>[CH2:14]([C:13]1[NH:19][C:17](=[O:18])[C:8]2[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:11][S:10][C:9]=2[N:12]=1)[CH3:15]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 10942334Sodium MethoxideHCID 673819684-Phenyl-2-propionylaminothiophene-3-carboxylic amide

Product 1

HCID 28868307HCID 28868307, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The solid 4-phenyl-2-propionylaminothiophene-3-carboxylic amide was added to a mixture of ethanol (50 ml) and sodium methoxide (2.24 g) and the resultant mixture was heated under reflux with stirring for 18 hours. The cooled mixture was diluted with water (300 ml) and acidified with concentrated hydrochloric acid. The resulting solid was collected by filtration, washed with water followed by acetonitrile and dried in vacuo to give 2-ethyl-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one (2.38 g), which was used without further purification.

Workup

  1. temperatureunder reflux
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-330c79ec9e6a49a885c08a4ddfe44480
Source dataset
uspto-grants-2011_09
Patent number
US08022076B2

Reaction notes

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