Hydrazine hydrate (1:1) → HCID 178506534, compound

HRID 910216Notes

Reaction equation

HRID 910216 reaction equation
O.[NH2:2]N.C[N:5](C)/[CH:6]=[CH:7]/[C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]=[C:18]3[CH:23]=[CH:22][C:21]([I:24])=[CH:20][N:19]3[CH:25]=2)=[CH:12][CH:11]=1)=O>C(O)C>[I:24][C:21]1[CH:22]=[CH:23][C:18]2[N:19]([CH:25]=[C:16]([C:13]3[CH:14]=[CH:15][C:10]([C:8]4[CH:7]=[CH:6][NH:5][N:2]=4)=[CH:11][CH:12]=3)[N:17]=2)[CH:20]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 16735150HCID 16735150, compound

Product 1

HCID 178506534HCID 178506534, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine monohydrate (100 μL) was added to a solution (30 mL) of (E)-3-(dimethylamino)-1-[4-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl]-2-propen-1-one (344 mg) in ethanol, and the mixture was refluxed for 3 hours. The reaction mixture was left to cool, and the precipitated matter was recovered through filtration and dried, to thereby yield the title compound (290 mg).

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. waitThe reaction mixture was left
  3. temperatureto cool
  4. filtrationthe precipitated matter was recovered through filtration
  5. customdried

Sources & evidence

ORD record
ord-cb8dea12f2d948b5ad772e2b6e2c5027
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

Loading…