反应详情

2-Amino-5-bromopyrimidine (348 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (532 mg) were suspended in 1,4-dioxane (20 mL), followed by refluxing under heating overnight. Immediately after refluxing, the reaction mixture was filtered without being cooled, followed by washing with heated 1,4-dioxane and drying, to thereby yield the title compound (587 mg).

1. temperatureby refluxing
2. temperatureunder heating overnight
3. temperatureImmediately after refluxing
4. filtrationthe reaction mixture was filtered
5. temperaturewithout being cooled
6. washby washing with heated 1,4-dioxane
7. customdrying