2-Amino-5-methylpyridine → 5-[4-(6-Methylimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazole

HRID 910226Notes

Reaction equation

HRID 910226 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:23][CH:22]=[N:21][CH:20]=2)=[CH:15][CH:14]=1)=O>>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[O:23][CH:22]=[N:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 153482-Amino-5-methylpyridineHCID 866318862-Bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone

Product 1

HCID 252041825-[4-(6-Methylimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazoleYield 43.6%

Procedure

The procedure of Referential Example 1 was repeated, except that 2-amino-5-methylpyridine (54 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (133 mg), which had been produced in Referential Example 10, were used, to thereby yield the title compound (60 mg).

Workup

  1. customhad been produced in Referential Example 10

Sources & evidence

ORD record
ord-e1b7286e2fc04aeeb308469cc9d550ec
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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