反应详情

温度

0 °C

2.5 ml (2.5 mmol) of ethanolic 1M hydrochloric acid solution are added dropwise to a solution of 1.1 g (2.5 mmol) of 2(S)-ethoxy-3-{4-[6-(3-heptyl-1-methylureido)pyrid-2-yl]phenyl}propanoic acid in 2 ml of ethanol, cooled to 0° C. The reaction medium precipitates. After filtration, the precipitate is washed with acetone and with ethyl ether and then dried. After hot recrystallization from a 9/1 acetone/water mixture, 0.6 g (60%) of 2(S)-ethoxy-3-{4-[6-(3-heptyl-1-methylureido)pyrid-2-yl]phenyl}propanoic acid hydrochloride is obtained in the form of a white solid with a melting point of 166° C.

1. customThe reaction medium precipitates
2. filtrationAfter filtration
3. washthe precipitate is washed with acetone and with ethyl ether
4. customdried
5. customAfter hot recrystallization from a 9/1 acetone/water mixture