Trifluoroacetic acid → HCID 67148013, compound

HRID 910313Notes

Reaction equation

HRID 910313 reaction equation
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C@@H:16]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:32]=[C:31]([CH2:33][NH:34][CH2:35]C(OC(C)(C)C)=O)[S:30][CH:29]=2)=[CH:24][CH:23]=1)[C:17]([O:19][CH3:20])=[O:18])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C@@H:16]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:32]=[C:31]([CH2:33][NH:34][CH3:35])[S:30][CH:29]=2)=[CH:24][CH:23]=1)[C:17]([O:19][CH3:20])=[O:18])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67148549HCID 67148549, compound

Product 1

HCID 67148013HCID 67148013, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.9 g (5 mmol) of methyl 2(S)-(2-benzoylphenylamino)-3-(4-{5-[(tert-butoxycarbonylmethylamino)methyl]thiophen-3-yl}phenyl)propanoate are placed in 30 ml of dichloromethane and 2.5 ml (32 mmol) of trifluoroacetic acid. After stirring at room temperature for 18 hours, the reaction medium is evaporated to dryness. 2.4 g (100%) of methyl 2(S)-(2-benzoylphenylamino)-3-[4-(5-methylaminomethylthiophen-3-yl)phenyl]propanoate are obtained.

Workup

  1. customthe reaction medium is evaporated to dryness

Sources & evidence

ORD record
ord-2d44a6b383c84f708c9354dfd96ba19c
Source dataset
uspto-grants-2011_09
Patent number
US08022079B2

Reaction notes

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