Triethyl phosphite → Ethyl (diethoxyphosphoryl)ethoxyacetate

HRID 910322Notes

Reaction equation

HRID 910322 reaction equation
Cl[CH2:2][CH2:3][O:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[P:11]([O:18]CC)([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14]>>[CH2:13]([O:12][P:11]([CH2:2][CH2:3][O:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])([O:15][CH2:16][CH3:17])=[O:18])[CH3:14]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 10964894Ethyl 2-(2-chloroethoxy)acetate

Product 1

HCID 15729465Ethyl (diethoxyphosphoryl)ethoxyacetateYield 100%

Procedure

36.3 g (218 mmol) of ethyl chloroethoxyacetate and 37.4 ml (218 mmol) of triethyl phosphite are heated at 50° C. for 3 hours. The reaction medium is evaporated to dryness under vacuum. 57 g (100%) of crude ethyl (d iethoxyphosphoryl)ethoxyacetate are obtained.

Workup

  1. customThe reaction medium is evaporated to dryness under vacuum

Sources & evidence

ORD record
ord-830901ebf3824f7f9910b2e3512eaff5
Source dataset
uspto-grants-2011_09
Patent number
US08022079B2

Reaction notes

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