HCID 178433880, compound → HCID 178433882, compound

HRID 910334Notes

Reaction equation

HRID 910334 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:9]2[N:32]=[C:31]([CH3:33])/[C:12](=[N:13]/[NH:14][C:15]3[CH:16]=[CH:17][CH:18]=[C:19]([C:22]4[CH:23]=[CH:24][CH:25]=[C:26]([C:28]([OH:30])=[O:29])[CH:27]=4)[C:20]=3[OH:21])/[C:10]2=[O:11])=[CH:6][C:7]=1[CH3:8]>C(O)CCCC>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:9]2[N:32]=[C:31]([CH3:33])/[C:12](=[N:13]/[NH:14][C:15]3[CH:16]=[CH:17][CH:18]=[C:19]([C:22]4[CH:23]=[CH:24][CH:25]=[C:26]([C:28]([OH:30])=[O:29])[CH:27]=4)[C:20]=3[OH:21])/[C:10]2=[O:11])=[CH:6][C:7]=1[CH3:8].[CH2:10]([CH2:12][NH2:13])[OH:11]

Participants

3

Reactant 1

HCID 178433880HCID 178433880, compound

Product 1

HCID 178433882HCID 178433882, compound

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Conditions

Temperature
70 °C

Procedure

Eltrombopag (15-20 mg) bisethanolamine was dissolved in 5 mL of 1-pentanol with heating to 70° C. and then was left to crystallize at 22° C. A precipitate formed and was separated by filtration and analysed. PXRD analysis provided the diffractogram as shown in FIG. 29.

Workup

  1. waitwas left
  2. customto crystallize at 22° C
  3. customA precipitate formed
  4. customwas separated by filtration
  5. customPXRD analysis provided the diffractogram

Sources & evidence

ORD record
ord-74417f6d935347e8b61a3ebb2e9216b7
Source dataset
uspto-grants-2011_09
Patent number
US08022093B2

Reaction notes

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