Diethylamine → HCID 67389608, compound

HRID 910473Notes

Reaction equation

[CH2:1]([O:3][C@H:4]([CH3:51])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C@@H:14]2[C@@H:19]([O:20][CH2:21][C:22]3[CH:23]=[CH:24][C:25]4[O:30][CH2:29][CH2:28][N:27]([CH2:31][CH2:32][CH2:33][O:34][CH3:35])[C:26]=4[CH:36]=3)[CH2:18][N:17]([S:37]([C:40]3[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=3)(=[O:39])=[O:38])[C@@H:16]([CH2:47][C:48](O)=[O:49])[CH2:15]2)=[CH:10][CH:9]=1)[CH3:2].[CH2:52]([NH:54][CH2:55][CH3:56])[CH3:53]>>[CH2:52]([N:54]([CH2:55][CH3:56])[C:48](=[O:49])[CH2:47][C@H:16]1[CH2:15][C@H:14]([C:11]2[CH:10]=[CH:9][C:8]([CH2:7][O:6][CH2:5][C@H:4]([O:3][CH2:1][CH3:2])[CH3:51])=[CH:13][CH:12]=2)[C@@H:19]([O:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]3[O:30][CH2:29][CH2:28][N:27]([CH2:31][CH2:32][CH2:33][O:34][CH3:35])[C:26]=3[CH:36]=2)[CH2:18][N:17]1[S:37]([C:40]1[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=1)(=[O:38])=[O:39])[CH3:53]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 67389861HCID 67389861, compound

Product 1

HCID 67389608HCID 67389608, compound

Procedure

According to general procedure D, 1.0 mmol of [(2R,4R,5R)-4-[4-((R)-2-ethoxy-propoxymethyl) -phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-acetic acid (example 1g) are reacted with diethylamine to afford the title compound, which is identified based on its Rf value.

Sources & evidence

ORD record: ord-a664bb2834154ebc8d6d748ea9a6d842
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022069B2

Reaction notes

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