Acetic Acid → HCID 86628492, compound

HRID 910583Notes

Reaction equation

HRID 910583 reaction equation
[CH2:1]([C:8]1[C:9](=[O:16])[NH:10][NH:11][C:12]=1[CH:13]([CH3:15])[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:17](O)=[O:18].C(O)(=O)C>O1CCCC1.C(O)(=O)C>[CH2:1]([C:8]1[C:9](=[O:16])[NH:10][N:11]([CH:17]=[O:18])[C:12]=1[CH:13]([CH3:14])[CH3:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 284Formic AcidHCID 673516914-Benzyl-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one

Product 1

HCID 86628492HCID 86628492, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 8028TetrahydrofuranSolvent

Procedure

4-Benzyl-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one (1.00 g) was dissolved in tetrahydrofuran (10 mL) at room temperature. A mixed anhydride of formic acid and acetic acid (0.489 g) and acetic acid (0.0140 g) were successively added to the solution. After stirring the reaction mixture at room temperature for 5 hours, the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane:ethyl acetate=4:1) to give 4-benzyl-1,2-dihydro-1-formyl-5-isopropyl-3H-pyrazol-3-one (1.07 g).

Workup

  1. customthe solvent was removed under reduced pressure
  2. customThe residue was purified by column chromatography on silica gel (eluent: n-hexane:ethyl acetate=4:1)

Sources & evidence

ORD record
ord-0eaf0d69506f488688f71efe4a5b7257
Source dataset
uspto-grants-2011_09
Patent number
US08022192B2

Reaction notes

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