反应详情

4-Benzyl-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one (1.00 g) was dissolved in tetrahydrofuran (10 mL) at room temperature. A mixed anhydride of formic acid and acetic acid (0.489 g) and acetic acid (0.0140 g) were successively added to the solution. After stirring the reaction mixture at room temperature for 5 hours, the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane:ethyl acetate=4:1) to give 4-benzyl-1,2-dihydro-1-formyl-5-isopropyl-3H-pyrazol-3-one (1.07 g).

1. customthe solvent was removed under reduced pressure
2. customThe residue was purified by column chromatography on silica gel (eluent: n-hexane:ethyl acetate=4:1)