反应详情

1 M NaOH (1.42 ml) was added to an EtOH suspension (3 ml) of methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate (115 mg), followed by stirring at room temperature for 8 hours. 1 M HCl (1.42 ml) was added to the reaction solution, followed by concentration under reduced pressure. Water (20 ml) was added to the residue, followed by stirring for 20 minutes. The precipitate formed was collected by filtration and dried under reduced pressure at 60° C. to obtain 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid (92 mg).

1. concentrationfollowed by concentration under reduced pressure
2. additionWater (20 ml) was added to the residue
3. stirringby stirring for 20 minutes
4. customThe precipitate formed
5. filtrationwas collected by filtration
6. customdried under reduced pressure at 60° C.