反应详情

温度

100 °C

Methyl 4-(2-oxo-1,2-dihydropyridin-3-yl)benzoate (316 mg) was suspended in toluene (7 mL), and 1-methyl-4-piperidinol (318 mg) and cyanomethylenetrimethylphosphorane (317 mg) were added thereto, followed by stirring at 100° C. for 1 hour. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol/chloroform=0% to 10%) to obtain methyl 4-[1-(1-methylpiperidin-4-yl)-2-oxo-1,2-dihydropyridin-3-yl]benzoate (85 mg) as a colorless oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (methanol/chloroform=0% to 10%)