Dimethylformamide dimethyl acetal → HCID 67387591, compound

HRID 910671Notes

Reaction equation

HRID 910671 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7]([NH2:9])=[O:8])[S:5][CH:6]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH3:12][N:13]([CH:15]=[N:9][C:7]([C:4]1[S:5][CH:6]=[C:2]([Br:1])[CH:3]=1)=[O:8])[CH3:14]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 128360674-Bromothiophene-2-carboxamide

Product 1

HCID 67387591HCID 67387591, compound

Conditions

Temperature
85 °C

Procedure

A mixture of 4-bromo-thiophene-2-carboxylic acid amide (206 mg, 1.0 mmol) and N,N-dimethylformamide dimethyl acetal (0.5 mL, 3.8 mmol) was heated at 85° C. for 1.5 h. The resulting mixture was cooled, and then concentrated under high vacuum to yield 4-bromo-thiophene-2-carboxylic acid dimethylaminomethyleneamide as a light tan solid, which was directly used in the next step without purification.

Workup

  1. temperatureThe resulting mixture was cooled
  2. concentrationconcentrated under high vacuum

Sources & evidence

ORD record
ord-98e95d6af4a34550aadcf789223864fb
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

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