Lithium Hydroxide → HCID 25216687, compound

HRID 910683Notes

Reaction equation

HRID 910683 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]3[CH:23]=[C:22]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH:21]=[CH:20][N:19]=3)[CH:13]=2)=[CH:8][CH:7]=1)=[O:5])C.[Li+].[OH-]>CO.O>[CH3:30][N:27]1[CH2:28][CH2:29][N:24]([C:22]2[CH:21]=[CH:20][N:19]=[C:18]([C:14]3[CH:13]=[C:12]([C:9]4[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=4)[CH:17]=[CH:16][CH:15]=3)[CH:23]=2)[CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 25216559HCID 25216559, compound

Product 1

HCID 25216687HCID 25216687, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

To a solution of 3′-[4-(4-methyl-piperazin-1-yl)-pyridin-2-yl]-biphenyl-4-carboxylic acid ethyl ester (182 mg, 0.4 mmol) in MeOH/water (3:1, 4 mL) was added LiOH (48 mg, 2 mmol). The resulting mixture was stirred at room temperature overnight. The resulting mixture was concentrated and the resulting aqueous solution was adjusted to pH 7 by the addition of 1 N HCl. The resulting mixture was concentrated and the resulting residue was dissolved in MeOH, dried, and concentrated to yield the title compound as a white solid.

Workup

  1. concentrationThe resulting mixture was concentrated
  2. additionthe resulting aqueous solution was adjusted to pH 7 by the addition of 1 N HCl
  3. concentrationThe resulting mixture was concentrated
  4. dissolutionthe resulting residue was dissolved in MeOH
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-b1c9ba078a134368a9185c6c88a574bd
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

Loading…