1-Methylpiperazine → HCID 57613196, compound

HRID 910687Notes

Reaction equation

HRID 910687 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[N:5]=[CH:4][N:3]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)C>[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:2]2[CH:7]=[C:6]([C:8]3[S:9][CH:10]=[CH:11][CH:12]=3)[N:5]=[CH:4][N:3]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 249021114-Chloro-6-thiophen-2-yl-pyrimidine

Product 1

HCID 57613196HCID 57613196, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 4-chloro-6-thiophen-2-yl-pyrimidine (48 mg, 0.24 mmol) in ethanol (3 mL), was added 1-methylpiperazine (0.54 mL, 0.49 mmol). The resulting mixture was heated at 100° C. in a sealed tube for 2 h. The resulting mixture was concentrated and the resulting crude residue was purified by SiO2 chromatography (0-5% 2 M NH3 in MeOH/CH2Cl2) to yield the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated
  2. customthe resulting crude residue was purified by SiO2 chromatography (0-5% 2 M NH3 in MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-454d9e4f712b4901b33cc48dfdfd6996
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

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